Associação entre alterações cortiais e o transtorno deperessivo maior

TL;DRAbstract

Introduction: Psychiatric disorders are known to have genetic, biological and psychosocial causes. The atrophy of specific areas in the brain cortex is presented as one of the multiple biological causes associated with Major Depressive Disorder. Objective: To investigate and quantify possible morphometric changes in the brain cortex of subjects with Major Depressive Disorder using the Voxel-Based Morphometry method and correlate these changes with the disorder intensity. Methods: We have studied 25 subjects (average = 34,98,34 year) with MDD, diagnosed using the DSM-IV and CID-10 criteria, and 30 control subjects (average = 2,29,25 years), without psychiatric disorders. The HAD 1 scale and the Beck Depression Inventory were used as auxiliary tools. The subjects were submitted to Magnetic Resonance Imaging (T1, Elscint Prestige 2T, Haifa Israel), with 1mm isotropic voxels and no gap. The images were than processed and analyzed using SPM2, VBM2 and MarsBar5 softwares. The T-Students test

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