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Article10.1161/circ.120.suppl_18.s1089

Abstract 5419: Hypokalemia Blunts Left Ventricular Mass Regression in Hypertensive Patients During Losartan- or Atenolol-Based Treatment: The LIFE Echo-substudy

Marcello Chinali,Gerard P. Aurigemma,Peter M. Okin,Eva Gerdts,Kristian Wachtell,Sverre E. Kjeldsen+4 more-2009-11-03-Circulation
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TL;DRAbstract

Background: It has been reported that hypokalemia (HypoK) is associated with persistent ECG left ventricular (LV) hypertrophy in treated hypertensive patients. The aim of the present study was to assess the impact of HypoK on echocardiographic LV mass regression during aggressive antihypertensive treatment. Methods: We analyzed data from 863 patients in the LIFE echo substudy (age 66±7 years, 41% women) with available serum K + levels. Patients were dichotomized according to presence of HypoK (i.e. <3.90mmol/L, lowest quartile). LV mass regression after one year of treatment was compared among groups. Results: Patients with HypoK had similar mean age and gender distribution to patients with normal K + (all p=ns), but higher systolic and diastolic blood pressure (BP) and heart rate (all p<0.05). After one year, similar reduction among groups in both systolic and diastolic BP (p=ns) was found. In multivariate analysis controlling for differences in age, gender, baseline LV mass, hy

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Background: It has been reported that hypokalemia (HypoK) is associated with persistent ECG left ventricular (LV) hypertrophy in treated hypertensive patients. The aim of the present study was to assess the impact of HypoK on echocardiographic LV mass regression during aggressive antihypertensive treatment. Methods: We analyzed data from 863 patients in the LIFE echo substudy (age 66±7 years, 41% women) with available serum K + levels. Patients were dichotomized according to presence of HypoK (i.e. <3.90mmol/L, lowest quartile). LV mass regression after one year of treatment was compared among groups. Results: Patients with HypoK had similar mean age and gender distribution to patients with normal K + (all p=ns), but higher systolic and diastolic blood pressure (BP) and heart rate (all p<0.05). After one year, similar reduction among groups in both systolic and diastolic BP (p=ns) was found. In multivariate analysis controlling for differences in age, gender, baseline LV mass, hy

Keywords

MedicineAtenololHypokalemiaCardiologyLosartanInternal medicineLeft ventricular hypertrophyEcho (communications protocol)

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