Role of dorsal root ganglion glutaminase in nociception - A novel therapeutic target for inflammatory pain

TL;DRAbstract

Scope and Method of Study: The purpose of this study was to examine the distribution of the enzyme glutaminase in rat dorsal root ganglion and determine its potential as a target for analgesic development. The study used a combination of behavioral analysis and quantitative microscopy to investigate the distribution of glutaminase in the rat dorsal root ganglion, expression of glutaminase during inflammation, expression of glutaminase under conditions of nerve growth factor depletion, and effect of glutaminase inhibition on inflammation induced Fos expression in spinal cord.

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