Mechanisms of cardiovascular disease in the metabolic syndrome and type 2 diabetes mellitus : focus on adverse intermediate phenotypes

TL;DRAbstract

Introduction 9 Chapter 2Higher central fat mass and lower peripheral lean mass are 29 independent determinants of endothelial dysfunction in the elderly. Chapter 3Microalbuminuria and cardiovascular autonomic dysfunction 57 are independently associated with cardiovascular mortality, evidence for distinct pathways. Chapter 4The metabolic syndrome is associated with maladaptive carotid 75 remodeling. Chapter 5Clustering of metabolic syndrome traits is associated with 95 maladaptive carotid remodeling and stiffening.A 6-year longitudinal study Chapter 6Body composition as determinant of thrombin generation in plasma. Chapter 7Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: potential role of central adiposity and low-grade inflammation.

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