The role of the transcription factor Nrf2 in inflammation and regeneration

TL;DRAbstract

The objective of this thesis was to investigate the role of the transcription factor nuclear factor erythroid 2 related factor 2 (Nrf2) during inflammatory and degenerative processes. Nrf2 can be activated by reactive oxygen species (ROS) and induces the expression of genes encoding for cytoprotective and antioxidant enzymes. It has already been shown that elevated levels of ROS are present during inflammation, indicating a possible involvement of Nrf2. The study demonstrated that Nrf2 is not only cytoprotective and antioxidative during inflammation, but has also regulatory functions in these processes. Experiments using macrophages showed that early pro inflammatory mediators initiate a double tracked molecular machinery. Besides from the well-known fast-acting nuclear factor kappa-light-chain-enhancer of activated B cells (NF kappaB) signaling, which initiates the acute phase of inflammation, these mediators also induce Nrf2 with a time delay. The activation of Nrf2 depended on NADPH

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