Translational research on spinal cord injury and cell-based therapies : a focus on pain and sensorimotor disturbances

TL;DRAbstract

dorsal hemisection T13-L1) of adult rats has only marginal effects on severed axons (i.e. corticospinal axons were found more closely to the lesion site, but not not cross the lesion). This lack of axon regeneration could, however, be related to the characteristics of the scaffold material; the break-down products of poly(D,L)-lactide are acidic which may be detrimental for good integration of the scaffold within the spinal cord lesion; also the matrices used only supported seeding OEC on the matrix surface leaving the grafted cells directly exposed to the toxic environment of the injured spinal cord (Deumens 2006a).

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