Role of calcitonin gene-related peptide in nociception : Interactions with substance P and opioids

TL;DRAbstract

<p>This thesis presents a study of calcitonin gene-related peptide (CGRP) and its antagonist CGRP8-37 and the interactions with substance P and opioids on the transmission of presumed nociceptive information at the spinal cord level in the rat. Significant bilateral increases in hindpaw withdrawal latency (HWL) to heat and mechanical stimulation were induced dose-dependently by intrathecal administration of 5 or 10 but no 1 nmol of CGRP8-37. Intrathecal injection of 10 nmol of CGRP had no effects on the HWLs intrathecal injection of 5 nmol of substance P decreased the latency to both HWLs.</p><p>Intrathecal administration of 10 nmol of CGRP8-37 not only reversed the SP-induced decrease in latency to both hindpaw withdrawal responses but also mediated significant increases in response latency compared to basal levels in the hot-plate and Radall Selitto tests. The increased effects induced by CGRP8-37 were reversed dose-dependently by intrathecal administration of 11 or

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