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Open AccessArticle10.15690/vramn.v68i9.772

STRUCTURAL AND FUNCTIONAL ANALYSIS OF TUMOR GENOMES AND THE DEVELOPMENT OF TEST SYSTEMS FOR EARLY DIAGNOSIS, PROGNOSIS AND CANCER THERAPY OPTIMIZATION

Zaletaev Dv,V. V. Strelnikov,М. В. Немцова,О. В. Бабенко,Ekaterina Kuznetsova,V. V. Zemlyakova+7 more-2013-09-10-Annals of the Russian academy of medical sciences
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The article discusses results of the structural and functional analysis of molecular genetic abnormalities in various malignant tumors. Investigations have discovered more than 20 new markers for sporadic breast cancer. Several of them formed the test system, allowing the diagnosis with a specificity of 100%. Appearance of TMPRSS2/ERG4 chimeric gene is a frequent tumor-specific event, its expression is correlated with more aggressive forms of prostate cancer, may serve as a molecular marker for tumor cells and androgen assessment of tumor response to hormonal therapy. The effective systems for the early diagnosis of cervix and endometrium cancer were developed as well. Mutations in the VHL, deletions of chromosome 3 and methylation of several genes can predict the course and selection of effective therapy of clear cell kidney cancer, a number of molecular markers were identified for early diagnosis and prognosis of recurrence of bladder cancer. For diagnosis, prognosis and treatment of

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The article discusses results of the structural and functional analysis of molecular genetic abnormalities in various malignant tumors. Investigations have discovered more than 20 new markers for sporadic breast cancer. Several of them formed the test system, allowing the diagnosis with a specificity of 100%. Appearance of TMPRSS2/ERG4 chimeric gene is a frequent tumor-specific event, its expression is correlated with more aggressive forms of prostate cancer, may serve as a molecular marker for tumor cells and androgen assessment of tumor response to hormonal therapy. The effective systems for the early diagnosis of cervix and endometrium cancer were developed as well. Mutations in the VHL, deletions of chromosome 3 and methylation of several genes can predict the course and selection of effective therapy of clear cell kidney cancer, a number of molecular markers were identified for early diagnosis and prognosis of recurrence of bladder cancer. For diagnosis, prognosis and treatment of

Keywords

CancerEpigeneticsBreast cancerProstate cancerMedicineBladder cancerOvarian cancerTargeted therapy

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