Population pharmacokinetics of mefloquine for malaria prophylaxis in Australian soldiers deployed in East Timor
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Aims: To study the population pharmacokinetics of mefloquine for malaria prophylaxis in Australian soldiers deployed in East Timor in field conditions. Methods: The soldiers were on weekly mefloquine prophylaxis for 26 - 28 weeks. Following 3 daily loading doses of 250 mg mefloquine hydrochloride each, oral weekly maintenance of doses of 250 mg were taken by each soldier during military deployment between October, 2000 and February, 2001. The soldiers comprised 154 males and 7 females with a mean (range) weight of 81 kg (53 - 135 kg), height of 177 cm (157 - 192 cm), and age 26 years (18-51). Blood sampling was performed after the last dose of the loading dose and at week 4, 8 and 12 during maintenance dosing. Mefloquine concentrations were measured by HPLC. Population pharmacokinetic modeling was performed using NONMEM. Results: A one-compartment model was found to be adequate to describe the mefloquine concentration data. A NONMEM analysis resulted in a population model being develop
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Aims: To study the population pharmacokinetics of mefloquine for malaria prophylaxis in Australian soldiers deployed in East Timor in field conditions. Methods: The soldiers were on weekly mefloquine prophylaxis for 26 - 28 weeks. Following 3 daily loading doses of 250 mg mefloquine hydrochloride each, oral weekly maintenance of doses of 250 mg were taken by each soldier during military deployment between October, 2000 and February, 2001. The soldiers comprised 154 males and 7 females with a mean (range) weight of 81 kg (53 - 135 kg), height of 177 cm (157 - 192 cm), and age 26 years (18-51). Blood sampling was performed after the last dose of the loading dose and at week 4, 8 and 12 during maintenance dosing. Mefloquine concentrations were measured by HPLC. Population pharmacokinetic modeling was performed using NONMEM. Results: A one-compartment model was found to be adequate to describe the mefloquine concentration data. A NONMEM analysis resulted in a population model being develop
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