High fat diet differentially regulates olfactory receptors in the duodenum of obesity‐prone and obesity‐resistant rats

TL;DRAbstract

The gastrointestinal tract is an important factor in the regulation of food intake, nutrient sensing and nutrient absorption. Obesity‐prone Osborne‐Mendel (OM) rats are less sensitive to the satiating effects of a duodenal infusion of fatty acids than obesity‐resistant S5B/Pl (S5B) rats, suggesting that the gastrointestinal tract differentially senses the presence of fat in these two strains. Based on microarray analysis of the duodenal enterocytes, it was hypothesized that olfactory receptors present in the duodenum of OM and S5B rats were differentially regulated by the intake of a diet high in fat. OM and S5B rats were fed either a high fat diet or a low fat diet for 2 weeks, in which OM rats consumed more high fat diet than S5B rats. The mRNA levels of four olfactory receptors (OLR1744, OLR50, OLR124, OLR1507) were assessed from the duodenal enterocytes of these rats. The duodenal mRNA levels of OLR1744, OLR124 and OLR1507 were significantly elevated in OM rats fed the high fat die

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