In vitro drug sensitivity of trichophyton rubrum against griseofulvin, ketoconazole and fluconazole.

TL;DRAbstract

The invitro activity of griseofulvin, ketoconazole and fiuconazole was investigated against 50 isolates of Trichophyton rubrum. Ketoconazole was more active, inhibiting all the 50 isolates at a concentration of 5 μgm/ml (MIC range 0.5-5 μgm/ml). Griseofulvin (MIC range 2.5-20 μgm/ml) required 20 μgm/ml of the drug for inhibition of all the isolates. Fluconazole was least active as it inhibited only 2 isolates at a concentration of 20 μgm/ml, which was the upper limit of the test system.

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