Aging induced alterations in carotid baroreflex control of arterial blood pressure at rest and during dynamic exercise in humans

TL;DRAbstract

The arterial baroreflex is fundamental for evoking and maintaining appropriate cardiovascular adjustments to exercise. Given that exercise‐induced blood pressure (BP) responses appear exaggerated in older individuals, we sought to investigate how aging influences carotid baroreflex (CBR) regulation of BP during dynamic exercise. BP and heart rate (HR) were recorded at rest and during leg cycling performed at 50% HR reserve in 6 young (23±1 yr) and 6 older (60±1 yr) healthy men. Five second pulses of neck pressure and neck suction from +40 to −80 Torr were applied to determine the maximal gain (G MAX ) of the full CBR function curve and examine baroreflex resetting during exercise. G MAX was similar in both groups at rest and during exercise. However, in older subjects the operating point (OP) of the modeled function curve was located further away from the centering point (CP) and towards the reflex threshold, both at rest (OP minus CP; −12±3 vs. −3±4 mmHg, older vs. young, P<0.05) a

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