Adiponectin microinjection into the nucleus tractus solitarius causes decreases in blood pressure

TL;DRAbstract

Adiponectin (ADP) is a fat cell‐derived hormone, the concentrations of which are reduced in patients with obesity‐related diseases such as insulin resistance, metabolic syndrome and hypertension. Central administration of ADP has been shown to induce changes in glucose, lipids and body weight similar to those produced by peripheral injection, implicating the brain as a target for ADP. Studies demonstrating that increases in circulating peptide rapidly translate into increases in intracerebroventricular ADP and that ADP receptors are present in brain suggest that circulating ADP can reach and act in the brain. Recent studies from our laboratory have shown that ADP microinjection into the area postrema, a circumventricular structure implicated in cardiovascular control and energy homeostasis increases blood pressure (BP). The nucleus tractus solitarius (NTS), a medullary structure with reciprocal connections to/from AP which has well‐documented roles in cardiovascular regulation and ener

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