Confirmation of the guinea pig as an experimental model of inflammation with dietary-induced atherosclerosis

TL;DRAbstract

Inflammation plays a major role in the development of atherosclerotic vascular disease through its diverse affects on arterial wall biology and lipoprotein metabolism. Inflammatory cells are a prominent feature of atherosclerotic lesions, both in humans and cholesterol-fed animal models of atherosclerosis. Given the critical nature of inflammation, an ideal animal model of atherosclerosis should have a resemblance to the human disease in terms of both cholesterol and lipoprotein metabolism and the inflammatory process. The primary aim of this study was to develop the guinea pig as an experimental animal model of inflammation in dietary-induced atherosclerosis. A secondary aim was to compare the effects of a high-cholesterol diet either high or low in carbohydrate on inflammatory markers. Thirty male Hartley guinea pigs were randomly assigned to one of three diet treatments for 12 wk (Low-Cholesterol, High-Cholesterol/High-Carbohydrate and High-Cholesterol/Low-Carbohydrate Groups). Anim

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