Effect of the NSAID diclofenac on 99mTc-MAG3 and 99mTc-DTPA renography: A comparison study

TL;DRAbstract

563 Objectives To compare the effect of the NSAID diclofenac, which is the commonly used to relieve renal pain, on renography using 2 radionuclides, 99mTc-MAG3 and 99mTc-DTPA. Methods Renography studies were performed for 24 New Zealand White rabbits. The studies were performed initially in the control state and then repeated 20 minutes after a single i.v. dose of diclofenac (2mg/kg) two days later. Rabbits were first studied with 48MBq (1.3 mCi) of 99mTc-MAG3. After one week, studies were repeated using 96 MBq (2.6 mCi) 99mTc-DTPA. Animals were given i.v. administrations of 60 ml saline 30 minutes before each study. Studies were acquired using Gamma camera equipped with a low energy high resolution collimator interfaced with a computer. Images were acquired as 2 s frames for the first 1 min and every 30 s for 30 min on a matrix of 64x64. Time-activity curves were generated from regions of interest drawn over the whole kidneys. Time to peak activity (T max), time from peak to 50% activ

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