Clinical course of neurological disorders in experimental hemorrhagic stroke after treatment with interleukin-2 (ronkoleukinum)

TL;DRAbstract

Aim. To study the influence of recombinant interleukin-2 (Ronkoleukinum) on indicators of oxidative protein modification and severity of neurologic signs in rats with experimental hemorrhagic stroke. Methods. Oxidative protein modification (by aldehyde and carboxyl products), the survival rate, neurological deficit by McGrow Stroke-index and animal psychophysiological status were studied on the model of intracerebral hemorrhage in rats after treatment with 0.01 mg/kg of interleukin-2 (Ronkoleukinum). Results. The progression of experimental hemorrhagic stroke in rats was accompanied with typical pathophysiological signs - oxidative protein modification with following neurological and cognitive disorders, followed by death of experimental animals. Administration of interleukin-2 (Ronkoleukinum) 0.01 mg/kg hampered the processes of free radical proteins damage, therefore decreasing the mortality rate in animals with intracerebral hemorrhage. Animals that were administered interleukin-2 (

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