Prevalence of Idiopathic Reactive Hypoglycaemia and Impact of Fructo-Oligosaccharide Supplementation on Blood Glucose Variability

TL;DRAbstract

BACKGROUND:\nThe term idiopathic reactive hypoglycaemia (IRH) applies when a meal-induced dip in blood\nglucose, or symptoms of hypoglycaemia, follows high-starch, low-fibre meals in otherwise healthy\nindividuals. Due to inconsistency of its definition and debated clinical value, reported prevalence\nof this state varies. No consensus exists on optimal treatment of IRH, hence we wanted to\ninvestigate 1) the prevalence and characteristics of IRH, and 2) if diet supplementation of fibre\ncould improve the reactive glucose response in IRH.\nMETHODS:\n362 subjects (71 + 9 years, 146 females), all previously undiagnosed of dysglycaemia, who had\nparticipated in on of two case-control studies involving a oral glucose tolerance test (OGTT), were\nclassified according to WHO standards (type 2 diabetes mellitus (T2DM), impaired glucose\ntolerance (IGT), normoglycaemia (NGT)) or categorized as IRH if OGTT 1h- or 2h- capillary\nblood glucose (cBG) levels were ≤ 3.9 mmol/L or 1h- or 2h- glucose

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