The Y of hYperactivitY in Anorexia Nervosa: Role of neuropeptide Y in hyperactivity associated with Anorexia Nervosa

TL;DRAbstract

Anorexia Nervosa is a dramatic neuro-psychiatric disorder characterized by severe selective restriction of food intake, hypophagia and hypothermia but also behavioral hyperactivity. Behavioral hyperactivity aggravates the already serious food-deprived state of anorexia patients, hinders body-weight gain and increases the probability of relapse; therefore, it is an important target in the treatment of anorexia nervosa. The activity-based-anorexia (ABA) model of anorexia and is extensively used to investigate the underlying neurobiological systems involved in hyperactivity. The hypothalamus is considered the major brain site for regulation energy metabolism, because it can assess the immediate energy state of the organism and consists of several nuclei. These different nuclei communicate with each other by using neurotransmitters and neuropeptides. One of these neuropeptides is neuropeptide Y (NPY); it is considered to most potent orexigenic neuropeptide known and it heavily innervates t

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