Conjugated linoleic acid effects on specific adipose depots and muscles and the calpain system in geriatric male mice

TL;DRAbstract

Conjugated linoleic acid (CLA) slightly increases carcass protein in aged mice (Baker et al., 2005), but the biological mechanism by which this occurs is unknown. Geriatric (23 mo) male C57BL/6 mice were fed isoenergetic diets containing 0 or 1.68% methyl esters of CLA (50/50 cis ‐9, trans ‐11 and trans ‐10, cis ‐12) and 6 mice/treatment were harvested at 0, 1, 2, 4, 20 and 30 d post treatment feeding. CLA reduced (18%) feed intake for the first 7 d but did not alter intake thereafter. CLA decreased (12%) BW at d 4 but BW did not differ at other time points. Neither time nor CLA affected the wet weight (%BW) of the pectoral, gastrocnemius and soleus muscles nor the gastrocnemius muscle protein content. CLA had no effect on the gastrocnemius muscle m‐calpain content or on total calpain activity. CLA decreased (~23%) the wet weight (%BW) of subcutaneous and perirenal fat by d 2 and these depots were reduced (>70%) by d 30. CLA reduced (76%) the epidydimal fat pad weight starting at d

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