Abstract 5417: Peripheral Blood Monocytes Are Activated in Patients With Well Controlled Hypertension: Implications for the Understanding of the Residual Cardiovascular Risk

TL;DRAbstract

Hypertension is associated with significant risk of cardiovascular events which remains increased even in the setting of well controlled hypertension. This residual risk may be related to inflammation persisting in spite of sufficient blood pressure control. We have recently reported that monocytes show pro-inflammatory and pro-atherosclerotic phenotype (co-expression of the Fc-gamma receptor-CD16+ and LPS receptor-CD14+) in relation to atherosclerosis risk factors and that hypertension is the strongest independent predictor of CD16+CD14+ monocytes. It is thus possible that monocytes remain activated in spite of appropriate blood pressure control and thus may be in part responsible for residual risk. We studied 112 hypertensive subjects and 25 control non-hypertensive individuals matched for major risk factors. Hypertension was well controlled (<140/90) in 52 and poorly controlled in 60 pts. Cytokine production was assessed by ELISA. Results: The prevalence of CD14+CD16+ monocytes w

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