Complicações infecciosas em pacientes randomizados a receber transplante alogenico de celulas progenitoras hematopoieticas de sangue periferico ou de medula ossea

TL;DRAbstract

Very few data are available on the comparison of infectious complications in peripheral blood stem cell transplantation (PBSCT) and bone marrow transplant (BMT). The charts of all patients included in a randomized clinical trial comparing PBSCT (27 patients) and BMT (29 patients) were retrospectively reviewed. In the pre-engraftment period were analysed the duration of neutropenia and hospitalization, occurrence of infections and antibiotic use. In the post-engraftment period were analysed the occurrence and severity of acute and chronic GVHD, duration of cyclosporin-A and corticosteroids use, antibiotic prophylaxis and episodes of infection. Patients receiving PBSCT had shorter duration of neutropenia but there were no differences in the incidence of infections or duration of antibiotic therapy. Patients receiving PBSCT had a higher incidence of extensive chronic GVHD (65% vs. 39%, p=0.08), longer duration of cyclosporin-A use (risk ratio [RR] 1.97), corticosteroids (RR 1.66), antibac

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