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Article10.1161/circ.124.suppl_21.a17540

Abstract 17540: The CC Variant of Locus 9p21 Increases Coronary Disease Risk with High Values of Hs-CRP

Roberto Palma dos Reis,Bruno Silva,Hugo Café,Sónia Freitas,Ilídio Ornelas,G Guerra+3 more-2011-11-22-Circulation
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TL;DRAbstract

Recent genomic wide association studies have identified several loci associated with coronary artery disease (CAD) risk. Among them, SNP rs 1333049 in the locus 9p21 (variant CC) has demonstrated a solid association with CAD which has been replicated in several populations, namely ours. High sensibility C-reactive protein (hs-CRP) has also been associated with inflammatory activity and atherosclerosis. An eventual interaction among these two atherosclerotic markers is unknown. Aim: To explore the interaction between this homozygous genetic variant (CC) and hs-CRP plasmatic levels in the emergence of CAD. Methods: Case-control study with 1561 participants, 695 consecutive coronary patients (mean age 53.9±8.9 years, 78.8% male) and 838 controls without apparent CAD (mean age 52.0±11.4 years, 71% male) selected in order not to present significant differences in sex and age. The G/C variants were studied blindly using a combined technique of PCR and TaqMan. Hardy-Weinberg distribution was

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Recent genomic wide association studies have identified several loci associated with coronary artery disease (CAD) risk. Among them, SNP rs 1333049 in the locus 9p21 (variant CC) has demonstrated a solid association with CAD which has been replicated in several populations, namely ours. High sensibility C-reactive protein (hs-CRP) has also been associated with inflammatory activity and atherosclerosis. An eventual interaction among these two atherosclerotic markers is unknown. Aim: To explore the interaction between this homozygous genetic variant (CC) and hs-CRP plasmatic levels in the emergence of CAD. Methods: Case-control study with 1561 participants, 695 consecutive coronary patients (mean age 53.9±8.9 years, 78.8% male) and 838 controls without apparent CAD (mean age 52.0±11.4 years, 71% male) selected in order not to present significant differences in sex and age. The G/C variants were studied blindly using a combined technique of PCR and TaqMan. Hardy-Weinberg distribution was

Keywords

MedicineLocus (genetics)Internal medicineCardiologyCoronary heart diseaseGeneticsGene

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