The Effects of Pargyline, Clorgyline, Deprenyl and their Metabolites on Rat Peripheral and Central Biogenic Amines: A Comparison between Changes in Urine Excretion and Brain Concentrations

TL;DRAbstract

The chronic effects of pargyline, clorgyline, deprenyl and their metabolites on central and peripheral biogenic amines were evaluated in rats. The amines studies are phenylethylamine (PEA), p-tyramine (Ty), norepinephrine (NE) and tryptamine (TP). All analyses were carried out by mass fragmentography. Pargyline gave rise to three dealkylated products: benzylamine, N-methylbenzylamine and N-propargylbenzylamine (NPB). Of these three metabolites only NPB had in vivo monoamine oxidase (MAO) inhibitory properties. NPB like pargyline markedly elevated urine and brain PEA while only pargyline reduced peripheral and brain 5HT metabolism, suggesting that the metabolism of pargyline to NPB may be largely responsible for MAO type B inhibition. Pargyline, clorgyline, deprenyl, and NPB reduced NE and DA metabolism as reflected upon urine and brain concentrations of the metabolites. These effects remained evident 24 hours after termination of treatment. In contrast to their expected effects on urin

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