Detection of Nornicotine in Human Urine after Infusion of Nicotine

doi:https://doi.org/10.1007/978-3-0348-7457-1_6

Detection of Nornicotine in Human Urine after Infusion of Nicotine

G. Neurath,David N. Orth,F. Gerhard Pein-1991-01-01-Birkhäuser Basel eBooks

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TL;DRAbstract

The role of oxidative N-dealkylation as a pathway of the human metabolism of nicotine has been investigated after intravenous infusion of nicotine. Nornicotine has been found in the urine presenting evidence for the existence of this metabolic step. But, only less than 1% of the administered dose of nicotine is excreted as nornicotine possibly indicating rapid further metabolism.

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The role of oxidative N-dealkylation as a pathway of the human metabolism of nicotine has been investigated after intravenous infusion of nicotine. Nornicotine has been found in the urine presenting evidence for the existence of this metabolic step. But, only less than 1% of the administered dose of nicotine is excreted as nornicotine possibly indicating rapid further metabolism.

Keywords

NornicotineNicotineUrineOxidative metabolismPharmacologyChemistryMetabolismMedicine

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