How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia
Marka van Blitterswijk,Mariely DeJesus‐Hernandez,Rosa Rademakers-2012-11-16-Current Opinion in Neurology
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TL;DRAbstract
The discovery of C9ORF72 repeat expansions provides novel insights into the pathogenesis of ALS and FTD and highlights the importance of noncoding repeat expansions and RNA toxicity in neurodegenerative diseases.
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The discovery of C9ORF72 repeat expansions provides novel insights into the pathogenesis of ALS and FTD and highlights the importance of noncoding repeat expansions and RNA toxicity in neurodegenerative diseases.
Keywords
C9orf72Frontotemporal dementiaAmyotrophic lateral sclerosisTrinucleotide repeat expansionMyotonic dystrophyDiseaseBiologyMechanism (biology)
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