Failure of Lamivudine to Reverse Hepatitis B Virus-Associated Changes in ERK, Akt and Cell Cycle Regulatory Proteins
Ruth Chin,L. Earnest-Silveira,Bernd Koeberlein,Susanne Franz,Hanswalter Zentgraf,Scott Bowden+2 more-2008-02-01-Antiviral Therapy
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TL;DRAbstract
Lamivudine was ineffective in reversing the HBV-induced changes in signal transduction pathways and cell cycle regulatory proteins, indicating that the HBV-infected cells remained primed for oncogenic transformation despite viral suppression.
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Lamivudine was ineffective in reversing the HBV-induced changes in signal transduction pathways and cell cycle regulatory proteins, indicating that the HBV-infected cells remained primed for oncogenic transformation despite viral suppression.
Keywords
LamivudineHepatitis B virusCell cycleBiologyVirologyHepatocellular carcinomaProtein kinase BMAPK/ERK pathway
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