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Article10.1161/circ.124.suppl_21.a8238

Abstract 8238: Relationship Between Red Blood Cell Omega-3 Fatty Acid Index and Bleeding During Hospitalization for Acute Myocardial Infarction

Adam C. Salisbury,William S. Harris,Amit P Amin,Kimberly J. Reid,James H. O’Keefe,John A. Spertus-2011-11-22-Circulation
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Background: Omega-3 fatty acids have established cardiovascular benefits, but may also inhibit platelet aggregation and increase bleeding. If this platelet inhibition is clinically meaningful, patients with the highest omega-3 indices (red blood cell eicosapentaenoic plus docosahexaenoic acid), which reflect long-term omega-3 fatty acid intake, should be at the greatest bleeding risk, particularly in the setting of acute myocardial infarction (AMI) when patients are aggressively treated with antithrombotic agents and frequently undergo invasive procedures. Methods: We studied 1523 patients from 24 US centers who had their omega-3 index assessed at the time of AMI. The rates of serious bleeding (TIMI major & minor) and mild-moderate bleeding (TIMI minimal) were identified in patients with low (<4%), intermediate (4-8%) and high (>8%) omega-3 indices. We used separate hierarchical modified Poisson models to identify the independent association between the omega-3 index and blee

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Background: Omega-3 fatty acids have established cardiovascular benefits, but may also inhibit platelet aggregation and increase bleeding. If this platelet inhibition is clinically meaningful, patients with the highest omega-3 indices (red blood cell eicosapentaenoic plus docosahexaenoic acid), which reflect long-term omega-3 fatty acid intake, should be at the greatest bleeding risk, particularly in the setting of acute myocardial infarction (AMI) when patients are aggressively treated with antithrombotic agents and frequently undergo invasive procedures. Methods: We studied 1523 patients from 24 US centers who had their omega-3 index assessed at the time of AMI. The rates of serious bleeding (TIMI major & minor) and mild-moderate bleeding (TIMI minimal) were identified in patients with low (<4%), intermediate (4-8%) and high (>8%) omega-3 indices. We used separate hierarchical modified Poisson models to identify the independent association between the omega-3 index and blee

Keywords

MedicineMyocardial infarctionCardiologyInternal medicineOmega 3 fatty acidRed blood cellFatty acidBiochemistry

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