Synthesis of 5-(4-Morpholino-7, 8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)pyridin-2-amine
TL;DRAbstract
A novel thiopyrano [4,3-d]pyrimidine derivative compound 1 was synthesized with methyl dimethyl 3,3'-thiodipropionate as starting material through five steps, including cyclization, chlorination, substitution with morpholine and coupling with 5-bromopyridin-2-amine through Suzuki reaction. And its structure was confirmed by 1 H NMR and MS. The total yield of the five steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropionate).Compound 1 is an important intermediate in the design and synthesis of thiopyrano [4,3-d]pyrimidine derivatives small molecule inhibitors.Therefore, the synthesis of Compound 1 has an important significance in the the study of anticancer drugs.
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A novel thiopyrano [4,3-d]pyrimidine derivative compound 1 was synthesized with methyl dimethyl 3,3'-thiodipropionate as starting material through five steps, including cyclization, chlorination, substitution with morpholine and coupling with 5-bromopyridin-2-amine through Suzuki reaction. And its structure was confirmed by 1 H NMR and MS. The total yield of the five steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropionate).Compound 1 is an important intermediate in the design and synthesis of thiopyrano [4,3-d]pyrimidine derivatives small molecule inhibitors.Therefore, the synthesis of Compound 1 has an important significance in the the study of anticancer drugs.
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