The role of the ezrin-radixin-moesin (ERM) proteins in development and post-injury responses of central nervous system neurons

TL;DRAbstract

The ezrin-radbdn-moesin (ERM) family of proteins mediate diverse cytoskeletal processes, such as cell adhesion and morphology, as well as cell migration. These functions have primarily been elucidated in non-neuronal cell phenotypes, with only limited data pertaining to a role for ERM proteins in CNS neurons. The few studies examining ERM functions in neurons indicate that they contribute to important aspects of developmental neuron growth and morphogenesis; processes that must be precisely executed for the establishment of appropriate connectivity during brain development. Further alluding to their potential importance in the CNS was the identification of ezrin as a binding partner of the developmentally crucial cell adhesion molecule (CAM) L1. After completion of brain development, the mature CNS has very little capacity for regeneration and functional recovery following injury, partly because upon maturation neurons lose their intrinsic ability for substantial growth, but mainly bec

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