Letter to the Editor A novel noninvasive assessment of hepatic venous pressure gradient and portal pressure computed from computed tomography angiography

TL;DRAbstract

Cirrhosis is a severe and common digestive disease worldwide and is associated with a poor outcome. Portal hypertension (PHT) is a frequently encountered complication in cirrhotic patients [1–3]. Therefore, evaluation of portal pressure (PP) is urgently needed for the grading and staging of PHT. Direct measurement of PP is rarely performed due to significant invasiveness and potential complications. Hepatic venous pressure gradient (HVPG) is currently treated as the “gold standard” [1–4]. However, the invasiveness and technical difficulty greatly restrict its repeatable application. An index computed from computed tomography angiography (CTA) has recently demonstrated its diagnostic value compared with the “gold standard” [5, 6]. For instance, fractional flow reserve from coronary CTA showed good performance in the diagnosis of functional coronary stenosis in a multicenter randomized clinical controlled trial on 159 vessels in 103 patients [6]. On the basis of our previous study of

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