Cardiac growth patterns in response to chronic hypoxia in a neonatal rat model mimicking cyanotic heart disease.

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Cardiac growth patterns in response to chronic hypoxia in a neonatal rat model mimicking cyanotic heart disease.

Nabil J. Azar,Michel Nasser,Marwan El Sabban,Hala Bitar,Mounir Obeid,Ghassan Dbaibo+1 more-2003-01-01-PubMed

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TL;DRAbstract

Cardiac mass increases in response to chronic hypoxia were greater in the RV than the LV. This increase was mainly due to myocardial proliferation in the first four weeks of life. Although the three groups of hypoxic rats had significant elevations in DNA concentration compared with controls, there was a shift from proliferation to hypertrophy after week 4 of life. The age of the myocyte appears to be the most important factor in triggering proliferation in this hypoxic animal model.

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Cardiac mass increases in response to chronic hypoxia were greater in the RV than the LV. This increase was mainly due to myocardial proliferation in the first four weeks of life. Although the three groups of hypoxic rats had significant elevations in DNA concentration compared with controls, there was a shift from proliferation to hypertrophy after week 4 of life. The age of the myocyte appears to be the most important factor in triggering proliferation in this hypoxic animal model.

Keywords

Hypoxia (environmental)Muscle hypertrophyMedicineMyocyteInternal medicineHeart diseaseCardiologyHeart development

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