Asymptomatic Leprosy Infection among Blood Donors May Predict Disease Development and Suggests a Potential Mode of Transmission

doi:https://doi.org/10.1128/jcm.01305-15

Asymptomatic Leprosy Infection among Blood Donors May Predict Disease Development and Suggests a Potential Mode of Transmission

Isabela Maria Bernardes Goulart,Sérgio Araújo,Adilson Botelho Filho,Paulo Henrique Ribeiro de Paiva,Luíz Ricardo Goulart-2015-07-23-Journal of Clinical Microbiology

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TL;DRAbstract

Blood donor samples (1,007) were assessed for anti-phenolic glycolipid 1 (PGL-1) IgM antibodies and Mycobacterium leprae DNA presence, which had 3.8% and 0.3% positivity, respectively. After a 5-year follow-up period, six individuals with positive markers developed leprosy, raising the hypothesis that asymptomatic infection among blood donors may be an undisclosed mode of leprosy transmission via transfusion.

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Blood donor samples (1,007) were assessed for anti-phenolic glycolipid 1 (PGL-1) IgM antibodies and Mycobacterium leprae DNA presence, which had 3.8% and 0.3% positivity, respectively. After a 5-year follow-up period, six individuals with positive markers developed leprosy, raising the hypothesis that asymptomatic infection among blood donors may be an undisclosed mode of leprosy transmission via transfusion.

Keywords

LeprosyAsymptomaticMycobacterium lepraeImmunologyTransmission (telecommunications)AntibodyMedicineBlood transfusion

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