Einfluss von Kisspeptin-10 auf die knochengerichtete Migration und Invasion von Mammakarzinomzellen

TL;DRAbstract

Metastases in the bone are a frequent problem in advanced breast cancer since the morbidity of the individual patient is increasing which is on the other hand decreasing their quality of life. The development of new therapeutic approaches depends among other things on the detailed knowledge of the complex metastasis process. In the present study we examined the interaction of breast cancer cells while cocultured with bone cells after treatment with kisspeptin-10. Kisspeptin-10 is a post-translational modified protein of the KiSS-1 gene which has so far shown the strongest agonist activity at GPR54. In the present study the expression of GPR54 was tested human breast cancer tissue of 98 patients. We observed a homogeneous distribution pattern of GPR54 expression regardless of the individual receptor status of the tumor. Further it was investigated whether kisspeptin-10 influences the bone-directed migration and invasion of GPR54-positive breast cancer cell lines (MCF-7 and MDA-MB-231) i

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