Usage of chlorhexidine as an adjunct therapy in oral candidal infections

TL;DRAbstract

Candida-induced infection in the oral cavity is by far the commonest human fungal infection and manifests in a variety of clinical guises. The foremost reason for its high occurrence appears to be the wide array of predisposing factors, which facilitate the transformation of oral commensal Candida to a parasitic existence. Despite the availability of a number of effective antimycotics for the treatment of oral candidoses, failure of therapy is not uncommon owing to the unique milieu of the oral cavity where the flushing and diluent effect of saliva and the cleansing action of the oral musculature tend to reduce the drug concentration to sub-therapeutic levels. Chlorhexidine is widely prescribed in dentistry both as an antiseptic mouthwash and a denture disinfectant as an adjunct to other antifungals. Chlorhexidine has a broad spectrum of antimicrobial activity including Candida albicans and other common non-albicans yeast species. In this brief chapter we outline the anti-Candida effec

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