Abstract 9518: Miscarriage and Risk of Atherosclerosis, A Nationwide Cohort Study of One Million Women

TL;DRAbstract

Background: Atherosclerosis might share aetiology with adverse pregnancy events through metabolic and vascular pathology or inflammatory responses. Knowledge on risk of atherosclerotic diseases in women experiencing spontaneous abortion/miscarriage is limited. In this nationwide cohort study we aimed to examine risk of three different atherosclerotic conditions in women who had experienced miscarriage. Methods: In Danish registers, we identified women experiencing a miscarriage or giving birth to a live singleton from 1977-2008. Women aged ≥12 years and free of cardiovascular disease were followed for incident cases of myocardial infarction, cerebral infarction and renovascular hypertension. Using Poisson-regression we estimated incidence rate ratios with 95% confidence intervals for these conditions by history of miscarriages. Results: In 1,031,279 women followed for more than 15 million person-years, we identified 2,798 incident cases of myocardial infarction, 4,053 incident cerebral

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