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Article10.1161/circ.120.suppl_18.s1087

Abstract 5337: Morphological Characteristics of the Culprit Lesion Correlate With the Angiographic Flow Grade Following Thrombolysis in Myocardial Infarction. An Optical Coherence Tomography Study

Αντώνιος Καρανάσος,Konstantinos Toutouzas,Maria Drakopoulou,Αndreas Synetos,Maria Riga,Eleftherios Tsiamis+4 more-2009-11-03-Circulation
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TL;DRAbstract

Background: Intravenous thrombolysis fails to restore blood flow in a significant percentage of patients with ST-elevation myocardial infarction (STEMI). It remains unknown, whether certain morphological characteristics of the culprit lesion (CL) can predict the success of thrombolysis. We hypothesized that the thickness of the fibrous cap and the incidence of plaque rupture at the CL, as measured by Optical Coherence Tomography (OCT), may correlate with the outcome of thrombolysis. Methods: We prospectively enrolled 55 consecutive patients with STEMI that were treated with thrombolysis 6 hours from symptom onset. All patients underwent coronary angiography within 24 hours from thrombolysis. We estimated TIMI flow grade and the corrected TIMI frame count (CTFC) for patients with TIMI flow II or III. In target vessels with TIMI flow grade ≤1 aspiration thrombectomy was performed. We then acquired OCT images from the CL. We measured the fibrous cap thickness (FCT) at the thinnest part ov

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Background: Intravenous thrombolysis fails to restore blood flow in a significant percentage of patients with ST-elevation myocardial infarction (STEMI). It remains unknown, whether certain morphological characteristics of the culprit lesion (CL) can predict the success of thrombolysis. We hypothesized that the thickness of the fibrous cap and the incidence of plaque rupture at the CL, as measured by Optical Coherence Tomography (OCT), may correlate with the outcome of thrombolysis. Methods: We prospectively enrolled 55 consecutive patients with STEMI that were treated with thrombolysis 6 hours from symptom onset. All patients underwent coronary angiography within 24 hours from thrombolysis. We estimated TIMI flow grade and the corrected TIMI frame count (CTFC) for patients with TIMI flow II or III. In target vessels with TIMI flow grade ≤1 aspiration thrombectomy was performed. We then acquired OCT images from the CL. We measured the fibrous cap thickness (FCT) at the thinnest part ov

Keywords

MedicineThrombolysisOptical coherence tomographyMyocardial infarctionCulpritCardiologyLesionRadiology

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