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Open AccessDissertation10.26481/dis.20141017bb

Mitochondria, lipotoxicity and skeletal muscle metabolism : implications for type 2 diabetes mellitus

TL;DRAbstract

Targeting of mitochondrial reactive oxygen species production does not avert lipidinduced insulin resistance in muscle tissue from mice Chapter 3 A two-week treatment with 2,4-dinitrophenol does not affect muscle substrate oxidation and glucose homeostasis in WT and db/db mice Chapter 4 A genistein-enriched diet does not improve skeletal muscle oxidative capacity or prevent the transition toward advanced stages of insulin resistance in ZDF rats Chapter 5 The mitochondrial protein mitoNEET: a study of its role in mitochondrial oxidative capacity, substrate metabolism, and lipid accumulation in skeletal muscle in rats Chapter 6 Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipidchallenged conditions, but leads to sudden cardiac death Chapter 7

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Targeting of mitochondrial reactive oxygen species production does not avert lipidinduced insulin resistance in muscle tissue from mice Chapter 3 A two-week treatment with 2,4-dinitrophenol does not affect muscle substrate oxidation and glucose homeostasis in WT and db/db mice Chapter 4 A genistein-enriched diet does not improve skeletal muscle oxidative capacity or prevent the transition toward advanced stages of insulin resistance in ZDF rats Chapter 5 The mitochondrial protein mitoNEET: a study of its role in mitochondrial oxidative capacity, substrate metabolism, and lipid accumulation in skeletal muscle in rats Chapter 6 Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipidchallenged conditions, but leads to sudden cardiac death Chapter 7

Keywords

LipotoxicitySkeletal muscleUCP3Insulin resistanceEndocrinologyInternal medicineMitochondrionBeta oxidation

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