DEVELOPMENT OF A NOVEL ORGAN CULTURE SYSTEM ALLOWING INDEPENDENT CONTROL OF LOCAL MECHANICAL VARIABLES AND ITS IMPLEMENTATION IN STUDYING THE EFFECTS OF AXIAL STRESS ON ARTERIAL REMODELING

TL;DRAbstract

Arterial remodeling is a process by which arteries respond to sustained changes in their mechanical environment. This process occurs in a way such that an artery's local mechanical environment (circumferential, shear, and axial stress) is maintained at a homeostatic level. However, most studies utilize a methodology that controls the global parameters (pressure, flow rate, and axial stretch). This approach often confounds the results since the actual drivers of remodeling are not independently isolated. This research involved developing a methodology and system capable of independently controlling each of the local parameters and examining the effect of axial stress on remodeling.
\n An organ culture system capable of monitoring and controlling the three global parameters and calculating the cross sectional geometry was developed. This combination of hardware was incorporated into LabVIEW which afforded the user the ability to define desired values for the local mechanical paramete

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