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Article10.1161/circ.125.suppl_10.a036

Abstract 036: The Association between Mid-Life Cardiorespiratory Fitness and Dementia in Later Life

Laura F. DeFina,Benjamin L. Willis,Ang Gao,Nina B. Radford,David Leonard,Jarett D. Berry-2012-03-13-Circulation
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TL;DRAbstract

Introduction: Prior literature suggests that higher levels of physical activity are associated with a lower risk for Alzheimer disease and related dementias (ADRD). However, the association between cardiorespiratory fitness (CRF) in healthy, middle aged adults and ADRD decades later in older age has not been studied. Methods: We included 20,195 participants (21.0% female, mean age 49.8 years, and free of vascular disease at baseline) enrolled in the Cooper Center Longitudinal Study (CCLS) between 1970 and 2009. CRF was measured by modified Balke protocol and treadmill time was used to estimate metabolic equivalents (METs) and to stratify CRF into low-, intermediate-, and high-fit categories. Baseline data from the CCLS were matched with Medicare administrative claims data from the Center for Medicare and Medicaid Services (CMS). The primary outcome variable was the diagnosis of ADRD as defined by CMS validated algorithms. We used a Cox proportional hazard model to estimate the associat

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Introduction: Prior literature suggests that higher levels of physical activity are associated with a lower risk for Alzheimer disease and related dementias (ADRD). However, the association between cardiorespiratory fitness (CRF) in healthy, middle aged adults and ADRD decades later in older age has not been studied. Methods: We included 20,195 participants (21.0% female, mean age 49.8 years, and free of vascular disease at baseline) enrolled in the Cooper Center Longitudinal Study (CCLS) between 1970 and 2009. CRF was measured by modified Balke protocol and treadmill time was used to estimate metabolic equivalents (METs) and to stratify CRF into low-, intermediate-, and high-fit categories. Baseline data from the CCLS were matched with Medicare administrative claims data from the Center for Medicare and Medicaid Services (CMS). The primary outcome variable was the diagnosis of ADRD as defined by CMS validated algorithms. We used a Cox proportional hazard model to estimate the associat

Keywords

MedicineCardiorespiratory fitnessGerontologyHazard ratioProportional hazards modelDiabetes mellitusDementiaMetabolic equivalent

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