Hepatoprotective effect of aqueous and pure extracts of raisin in alloxan-induced diabetic rats

TL;DRAbstract

Abstract .Thepresentstudywasconductedtoevaluatethepossibleantioxidanteffectsofraisinaqueousandpurextractof“Karkni”on liver histology, antioxidant enzymes activities and lipid peroxide levels in liver of diabetic and normal rats. 125mg/kg of pureand aqueous extract of “Karkni” were orally administered daily to alloxan-diabetic rats for 4 weeks. Alloxan- induced diabetic ratsshowed significant increases in the levels of total protein and malondialdehyde (MDA), glutathione peroxidase (GPx), catalase(CAT) and reduced glutathione (GSH) levels were significantly decreased compared to normal rats ( p <0.05). Also, no significanteffectsonglutathioneperoxidase(GPx)activityindiabeticratswereobserved.Thechangesoftheaboveparameterstotheirnormallevels after 4 weeks of treatment were observed mainly with the pure extract. The results suggesting that pure extract suppressesthe liver tissue inflammation attenuate lipid peroxidation and can be helpful in reducing liver damage caused by alloxan-induceddiabe

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