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METABOLIC ENGINEERING OF Saccharomyces cerevisiae FOR PRODUCTION OF ADIPIC ACID FROM RENEWABLE SOURCES

Emma Karlsson,Luigi D’Avino,Valeria Mapelli,Lisbeth Olsson-2014-01-01-Chalmers Research (Chalmers University of Technology)
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TL;DRAbstract

Adipic acid is a six carbon long dicarboxylic acid, considered to be the most important synthetic dicarboxylic acid annually produced, according to the International Energy Agency (IEA). The global production of adipic acid had in 2010 a volume of 2.8 million tonnes, for a total market price of 4.9 billion USD. The current production of adipic acid relies on non-renewable fossil raw materials, leading to emission of the greenhouse gases carbon dioxide and N2O. In addition, the production starts from benzene, whose use has several health related negative implications. This project aims to create a greener process for production of adipic acid developing a fermentation-based process using Swedish domestic renewable raw materials, such as forest residues and/or algae. These materials will be used to establish a biorefinery, wherein the fermentation process for the biosynthesis of adipic acid will represent the core process. Our current strategy is based on the generation of genetically mo

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Adipic acid is a six carbon long dicarboxylic acid, considered to be the most important synthetic dicarboxylic acid annually produced, according to the International Energy Agency (IEA). The global production of adipic acid had in 2010 a volume of 2.8 million tonnes, for a total market price of 4.9 billion USD. The current production of adipic acid relies on non-renewable fossil raw materials, leading to emission of the greenhouse gases carbon dioxide and N2O. In addition, the production starts from benzene, whose use has several health related negative implications. This project aims to create a greener process for production of adipic acid developing a fermentation-based process using Swedish domestic renewable raw materials, such as forest residues and/or algae. These materials will be used to establish a biorefinery, wherein the fermentation process for the biosynthesis of adipic acid will represent the core process. Our current strategy is based on the generation of genetically mo

Keywords

Adipic acidMetabolic engineeringFermentationIndustrial fermentationRaw materialBiorefineryChemistryLysine

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