Poliomyelitis in Japan during the period 1962-68 after the introduction of mass vaccination with Sabin vaccine.

TL;DRAbstract

After the mass vaccination of children of susceptible age groups in Japan in 1961, the incidence of poliomyelitis decreased markedly. From 1962 to 1968 a total of 659 paralytic cases were officially notified. Detailed investigations of 626 cases reported to the Poliomyelitis Surveillance Committee revealed that only 185 (29.6%) were cases of paralysis clinically typical of poliomyelitis. Tests on 120 of these 185 cases showed that 75 (62.5%) were positive for poliovirus: 45 of these positive cases were temporally associated with the administration of live poliovirus vaccine and 36 had some residual disability. Wild types of poliovirus were rarely isolated. Only 36 vaccine-related cases of poliomyelitis were observed among the total of more than 11 million newborn infants vaccinated with Sabin vaccine in the period 1962-68.

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