Acute Effects of a Glucagon‐Like Peptide 2 Analogue, Teduglutide, on Gastrointestinal Motor Function and Permeability in Adult Patients With Short Bowel Syndrome on Home Parenteral Nutrition

doi:https://doi.org/10.1177/0148607115597644

Acute Effects of a Glucagon‐Like Peptide 2 Analogue, Teduglutide, on Gastrointestinal Motor Function and Permeability in Adult Patients With Short Bowel Syndrome on Home Parenteral Nutrition

Johanna Iturrino,Michael Camilleri,Andrés Acosta,Jessica O’Neill,Duane D. Burton,Jithinraj Edakkanambeth Varayil+3 more-2015-07-28-Journal of Parenteral and Enteral Nutrition

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TL;DRAbstract

Seven-day TED treatment in 8 participants suggests beneficial effects on fluid balance and monosaccharide absorption, and it retarded overall gut transit with no effects on GE or mucosal permeability. Larger, longer, mechanistic studies of TED in SBS are warranted. This trial was registered at clinicaltrials.gov as NCT02099084.

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Seven-day TED treatment in 8 participants suggests beneficial effects on fluid balance and monosaccharide absorption, and it retarded overall gut transit with no effects on GE or mucosal permeability. Larger, longer, mechanistic studies of TED in SBS are warranted. This trial was registered at clinicaltrials.gov as NCT02099084.

Keywords

Short bowel syndromeMedicineInternal medicineParenteral nutritionLactuloseGastric emptyingGastroenterologyCrossover study

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