Prospective Evaluation of Maintenance Plasma Exchange (mPLEX) for Attack Prevention in Neuromyelitis Optica Spectrum Disorder: Preliminary Feasibility, Safety, and Efficacy Data (P5.265)

TL;DRAbstract

OBJECTIVE: To report preliminary data from a prospective study of mPLEX for neuromyelitis optica spectrum disorder (NMOSD). BACKGROUND: Rescue PLEX is often used for acute corticosteroid-refractory NMOSD attacks. Anecdotal and retrospective studies suggest a potential role for mPLEX in attack prevention but feasibility, safety, and optimal treatment regimen are unclear. DESIGN/METHODS: Prospective observational study of NMOSD patients (target n=14) planning to initiate mPLEX. Clinical and laboratory data were collected at screening and quarterly for 12 months. Treatment plans, including PLEX frequency, were at the treating neurologist’s discretion. RESULTS: 9 subjects were consented. Of the 6 subjects who received mPLEX, 5 were female, all were aquaporin-4 antibody (AQP4-IgG) seropositive, median age was 62y, and median disease duration was 7.6y. Reasons for mPLEX included drug treatment failure (n=3), avoidance of immunosuppression (n=1 each with progressive multifocal leukoencephalop

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