Comparison of porcine CD4 and gamma-delta T cell systemic and mucosal responses to the spirochete Brachyspira hyodysenteriae

TL;DRAbstract

CHAPTER 1. GENERAL INTRODUCTION I Background and rationale I Objectives of the dissertation 5 Dissertation organization 5 Literature review 6 Functional differences between aP and y8 T cells 6 Origin and distribution 6 Differential aspects of antigen recognition between ap and y8 T cells 7 Comparison and contrast between the (%P and yo T cell receptor 8 Structure of the T cell receptor 8 Differences between the (%P and y8 T cell receptor 12 Porcine CD4 T cells 13 Coexpression of CD8aa in mature porcine CD4T T cells 15 The CD8 coreceptor: isoforms, function and regulation of cell surface expression 16 Possible explanations for the function of mature CD4+CD8aaT cells 18 Porcine y8 T cells 19 Lymphocyte composition of the intestinal mucosa 21 Role of T cells in the development and regulation of intestinal inflammation 23 Cellular mechanisms involved in intestinal mucosa homeostasis 23 Role of CD4+ T cells in the establishment and resolution of inflammation 24 Y8 T cell involvement in the

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