Acidic extracellular microenvironment promotes the invasion and cathepsin B secretion of PC-3 cells.

Open AccessArticle

Acidic extracellular microenvironment promotes the invasion and cathepsin B secretion of PC-3 cells.

Li Gao,Youqiang Fang,Tianyu Zhang,Bo Ge,Rong-Jing Tang,Jiefu Huang+2 more-2015-01-01-PubMed

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TL;DRAbstract

Acidic microenvironment may significantly promote the invasion of PC-3 cells and increase the secretion of cathepsin B. This suggests that the acidic microenvironment induced invasion of PC- cells is related to the elevated cathepsin B secretion.

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Acidic microenvironment may significantly promote the invasion of PC-3 cells and increase the secretion of cathepsin B. This suggests that the acidic microenvironment induced invasion of PC- cells is related to the elevated cathepsin B secretion.

Keywords

SecretionAcridine orangeTumor microenvironmentCathepsin BWestern blotCathepsinExtracellularGentamicin protection assay

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