HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)
Gonzalo Lopez,Kate Lynn J. Bill,Hemant K. Bid,Danielle Braggio,Dylan Constantino,Bethany C. Prudner+4 more-2015-07-22-PLoS ONE
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TL;DRAbstract
MPNST is an aggressive sarcoma that is notoriously therapy-resistant, hence the urgent need for improved anti-MPNST therapies. HDAC8 inhibition may be useful for MPNST by improving efficacy while limiting toxicities as compared to pan-HDACis.
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MPNST is an aggressive sarcoma that is notoriously therapy-resistant, hence the urgent need for improved anti-MPNST therapies. HDAC8 inhibition may be useful for MPNST by improving efficacy while limiting toxicities as compared to pan-HDACis.
Keywords
Cancer researchCell growthBiologyCell cycleAnnexinHDAC8Cell cultureApoptosis
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