P1.3.11 Novel immune TiO2 photoluminescence biosenors for leucosis detection
TL;DRAbstract
Novel immune photoluminescent biosensor, based on TiO 2 nanoparticles, for retroviral leucosis detection has been developed. The photoluminescence spectra were excited by solid state laser with wavelength 355 nm and measured in the range of 370-800 nm. Original photoluminescence spectrum of TiO 2 nanoparticles showed wide maximum at 515 nm. The biosensitive layer was formed by immobilization of retroviral leucosis antigens on the surface of TiO 2 nanoparticles. Immobilization of antigens on TiO 2 surface led to UV-shift of photoluminescence spectrum and increase of PL intensity. The response to different concentrations of retroviral leucosis antibodies has been measured. The decrease of spectrum intensity and IR-shift were observed after antibodies adsorption on biosensor surface. The experimental dependences of maximum shift and intensity changes versus antibodies concentration were obtained.
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Novel immune photoluminescent biosensor, based on TiO 2 nanoparticles, for retroviral leucosis detection has been developed. The photoluminescence spectra were excited by solid state laser with wavelength 355 nm and measured in the range of 370-800 nm. Original photoluminescence spectrum of TiO 2 nanoparticles showed wide maximum at 515 nm. The biosensitive layer was formed by immobilization of retroviral leucosis antigens on the surface of TiO 2 nanoparticles. Immobilization of antigens on TiO 2 surface led to UV-shift of photoluminescence spectrum and increase of PL intensity. The response to different concentrations of retroviral leucosis antibodies has been measured. The decrease of spectrum intensity and IR-shift were observed after antibodies adsorption on biosensor surface. The experimental dependences of maximum shift and intensity changes versus antibodies concentration were obtained.
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