Further Characterization Of The Nodamura Virus Rna2 3'-Terminal Stem Loop Structure And Its Role In Viral Rna Replication

TL;DRAbstract

Nodamura virus (NoV) is an excellent model system for studying many aspects of the life cycle of positive-strand RNA viruses. NoV's simple genome organization and ability to replicate its genome to high levels in a wide variety of host cells, including plants, yeast, insects and mammals (Ball et al., 1992; Garzon et al., 1978, 1990; Murphy et al., 1970; Price et al., 2005; Scherer & Hurlbut, 1967; Selling et al., 1990; reviewed by Ball & Johnson, 1998), make it a prime model system for studying the basic mechanisms of viral RNA replication. Other positive-strand RNA viruses, including those that are pathogenic for humans, may share these mechanisms. Additionally, these studies together suggest that the host factors involved in NoV RNA replication must be widely conserved across many eukaryotic organisms. NoV is unique in its lethality for both invertebrates and mammals, as other nodaviruses are nonpathogenic for higher vertebrates (Bailey et al., 1975; Longworth & Carey, 19

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