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Article10.1096/fasebj.23.1_supplement.921.7

Iron status and LDL ‐ oxidation in a group of healthy adults from Argentina. Preliminary results

Silvia H Langini,Mabel Lardo,Sergio Ghersevich,María Rosario Aragone,Claudio Carbia,Marcela Pandolfo+3 more-2009-04-01-The FASEB Journal
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TL;DRAbstract

Excess body iron (Fe) has been proposed to oxidize low ‐density lipoproteins (LDL). Blood samples from 109 non‐institutionalized healthy adults attending Hospital Italiano, Buenos Aires during 2006 were obtained. Samples negative for C‐reactive protein (PCR‐latex, Wiener lab) and risk population were studied: men (M) 23‐95y (n=30) and postmenopausal women (PostW) 51‐83y (n=31). Serum ferritin (SF) (quimiolumminescence analyzer‐ DPC‐Siemmens); unsaturated iron binding capacity (UIBC) (FerroZine‐) (Hitachi 917; automated systems‐ Roche diagnostics) and plasma oxidized LDL (ox‐LDL) (competitive ELISA developed at UNR, School of Biochemical and Pharmaceutical Sciences, Argentina, normal range 2.2‐3.8 U) were measured. Mean values ± SD, (range) and % of individuals with normal values were: No correlation was found between ox‐LDL and SF (r= 0.02) nor UIBC (r=0.006) levels in M and PostW. However, increased risk of chronic diseases may be possible, as wheat flour fortification with Fe is mand

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Excess body iron (Fe) has been proposed to oxidize low ‐density lipoproteins (LDL). Blood samples from 109 non‐institutionalized healthy adults attending Hospital Italiano, Buenos Aires during 2006 were obtained. Samples negative for C‐reactive protein (PCR‐latex, Wiener lab) and risk population were studied: men (M) 23‐95y (n=30) and postmenopausal women (PostW) 51‐83y (n=31). Serum ferritin (SF) (quimiolumminescence analyzer‐ DPC‐Siemmens); unsaturated iron binding capacity (UIBC) (FerroZine‐) (Hitachi 917; automated systems‐ Roche diagnostics) and plasma oxidized LDL (ox‐LDL) (competitive ELISA developed at UNR, School of Biochemical and Pharmaceutical Sciences, Argentina, normal range 2.2‐3.8 U) were measured. Mean values ± SD, (range) and % of individuals with normal values were: No correlation was found between ox‐LDL and SF (r= 0.02) nor UIBC (r=0.006) levels in M and PostW. However, increased risk of chronic diseases may be possible, as wheat flour fortification with Fe is mand

Keywords

Iron statusFerritinChemistryMedicineFortificationPopulationSerum ferritinInternal medicine

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